Laboratory of
Cellular Energy Sensor
Professor Joohun Ha
Tel: 82-2-961-0921
Seoul, Korea
Dnagdaemung, Kyungheedaero 26
Medical Building Rm 428
Professor
Joohun Ha, Ph.D
Dr. Joohun Ha is a professor at Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, Seoul, Korea. He has received B.S. from University of California, Berkeley, in 1987, and Ph.D. from Purdue University in 1993. After training as a post-doctoral research fellow at Purdue University, he joined faculty member of Kyung Hee University in 1996. Ever since, he has been working on the regulatory mechanisms of energy homeostasis. Biochemical aspects between metabolic syndrome and cancer progression are the primary targets of his study, and he is now trying to develop drug candidates and materials for cosmetics
Education & Training
1996-present
Kyung Hee University
College of Medicine
Dept. of Biochemistry and Molecular Biology
2006-2007
Visiting Scholar
University of California, San Diego
1993-1996
Post-doc, Purdue University
1987-1996
Ph.D. Purdue University
1987-1996
B.S. University of California, Berkeley
Research Publications
Recent publications with impact factor (year 2020~2022)
1. (IF: 6.706) Song, M., Kim M., Hoang., D,…Ha, J (2022) A Hydrodistillate of Gynostemma pentaphyllum and Damulin B Prevent Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo via Regulation of AMPKα1 Transcription. Nutrients 14.
2. (IF: 6.706) Hwang, C. Y., Choe, W., Yoon, K. S., Ha, J., Kim, S. S., Yeo, E. J., and Kang, I. (2022). Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer. Nutrients 14.
3. (IF: 12.153) Tran, Q. H., Hoang, D. H., Song, M., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2021). Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKalpha1 transcription in human breast cancer cells. Exp Mol Med 53, 1413-1422.
4. (IF: 12.153) Yang, G., Song, M., Hoang, D. H., Tran, Q. H., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2020). Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKalpha2-dependent mitochondrial damage. Exp Mol Med 52, 2055-2068.
5. (IF: 6.085) Song, M., Lee, J., Kim, Y. J., Hoang, D. H., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2020). Jeju Magma-Seawater Inhibits alpha-MSH-Induced Melanogenesis via CaMKKbeta-AMPK Signaling Pathways in B16F10 Melanoma Cells. Mar Drugs 18.
6. (IF: 2.264) Song, M., Yang, G., Hoa, T. Q., Hieu, H. D., Amin, A. S. M., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2020). Anti-obesity Effect of Fermented Persimmon Extracts via Activation of AMP-Activated Protein Kinase. Biol Pharm Bull 43, 440-449.
7. (IF: 6.14) Nguyen, N. N. Y., Choi, T. G., Kim, J., Jung, M. H., Ko, S. H., Shin, Y., Kang, I., Ha, J., Kim, S. S., and Jo, Y. H. (2020). A 70-Gene Signature for Predicting Treatment Outcome in Advanced-Stage Cervical Cancer. Mol Ther Oncolytics 19, 47-56.
8. (IF: 3.322) Park, I. J., Tran, Q. H., Amin, A. S. M., Chu, T. L., Yang, G., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2018). Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. Biochem Biophys Res Commun 504, 367-373.
9. (IF: 3.322) Lee, J., Yang, G., Kim, Y. J., Tran, Q. H., Choe, W., Kang, I., Kim, S. S., and Ha, J. (2017). Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway. Biochem Biophys Res Commun 491, 733-739.
10. (IF: 7.050) Kim, J., Yang, G., and Ha, J. (2017). Targeting of AMP-activated protein kinase: prospects for computer-aided drug design. Expert Opin Drug Discov 12, 47-59.
11. (IF: 12.153) Kim, J., Yang, G., Kim, Y., Kim, J., and Ha, J. (2016). AMPK activators: mechanisms of action and physiological activities. Exp Mol Med 48, e224.
12. (IF: 6.208) Chung, J., Huda, M. N., Shin, Y., Han, S., Akter, S., Kang, I., Ha, J., Choe, W., Choi, T. G., and Kim, S. S. (2021). Correlation between Oxidative Stress and Transforming Growth Factor-Beta in Cancers. Int J Mol Sci 22.
13. (IF: 6.706) Kim, K., Lee, Y. S., Jeong, S., Kim, D., Chon, S., Pak, Y. K., Kim, S., Ha, J., Kang, I., and Choe, W. (2020). A Small Molecule, 4-Phenylbutyric Acid, Suppresses HCV Replication via Epigenetically Induced Hepatic Hepcidin. Int J Mol Sci 21.
Awards
- 2017 -
Science and Technology Excellent Journal
KFSTS
- 2017 -
Chung San Award
KSBMB
- 2010 -
The most frequently cited paper
KSBMB
- 2007 -
Ilchon Young Scientist
KSBMB
Awards
- 2017 -
Science and Technology Excellent Journal
KFSTS
- 2017 -
Chung San Award
KSBMB
- 2010 -
The most frequently cited paper
KSBMB
- 2007 -
Ilchon Young Scientist
KSBMB
- 2007, 2008, 2009 -
Excellent Research Award
Kyung Hee University